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KO-0032 – McMaster University Endurance Performance Study

by Paul Booth 08 Oct 2026

KO-0032 – McMaster University Endurance Performance Study

Knowledge Object ID: KO-0032

Category: Scientific Evidence • Independent University Research

Published In: International Journal of Sports Nutrition


Executive Summary

The McMaster University investigation was an independent, randomized, double-blind study comparing PerformanceDrink with Gatorade and a water placebo during prolonged endurance exercise. 

PerformanceDrink 80 cal Gatorade 160 cal

Unlike the University at Buffalo study, which integrated both physical and cognitive performance, the McMaster investigation concentrated primarily on endurance performance, exercise capacity, and physiological responses.

Together, the two university studies provide complementary evidence supporting both the physical and cognitive aspects of human performance.


Study Design

Institution

McMaster University

Study Design

  • Independent
  • Randomized
  • Double-blind
  • Placebo-controlled
  • Head-to-head comparison with Gatorade
  • Water placebo control

This design minimizes investigator and participant bias while allowing direct comparison between beverages.


Study Objective

Researchers evaluated whether PerformanceDrink could improve endurance exercise performance compared with:

  • Gatorade®
  • Water placebo

Primary outcomes included:

  • Time to exhaustion
  • Exercise endurance
  • Physiological performance
  • Carbohydrate utilization

Physical Performance Results

The McMaster study demonstrated substantial improvements in endurance performance.

Published Results

Outcome PerformanceDrink
Average improvement in endurance performance 24%
Minimum improvement observed 9%
Exercise protocol Prolonged endurance cycling
Comparison beverages Gatorade and Placebo

The published study reported an average endurance improvement of 24%, with every participant demonstrating improvement and the smallest improvement measured being 9%.  PerformanceDrink 80 cal Gatorade 160 cal

This consistency is notable because improvements were observed across all participants rather than being driven by only a few individuals. Gatosde results where not good engh to publish. 


Comparison Summary

Beverage Relative Endurance Performance
PerformanceDrink Highest 39.5% better
Gatorade Lower
Water Placebo Lowest

Physiological Interpretation

The McMaster investigation suggests that the formulation supported prolonged exercise performance under controlled laboratory conditions.

The findings are consistent with PerformanceDrink's design goals of supporting:

  • sustained carbohydrate availability
  • hydration
  • prolonged exercise
  • endurance capacity

The study itself does not establish the physiological mechanism responsible for the observed improvements, and multiple factors may contribute.


Relationship to the Buffalo Study

The McMaster and University at Buffalo investigations complement one another.

McMaster University at Buffalo
Endurance physiology Physical + Cognitive performance
Exercise capacity Exercise + ANAM cognitive testing
Time to exhaustion Reaction time, memory, attention, spatial processing
Exercise performance Integrated physical and cognitive performance

Together they demonstrate that PerformanceDrink was evaluated across multiple dimensions of athletic performance.


Integrated University Evidence

When both university investigations demonstrated PerformanceDrink was superior McMaster University 

  • Average endurance improvement: 24%
  • Minimum improvement: 9%

University at Buffalo

  • 9.5% PerformanceDrink greater total power output than Gatorade.
  • 36.1% PerformanceDrink greater total power output than placebo.
  • Significant improvement in 6 of 7 cognitive categories.
  • Combined physical and cognitive advantage:
    • 38.5% versus Gatorade.
    • 108% versus placebo.

Scientific Significance

The two university studies evaluated different aspects of performance.

McMaster established improvements in endurance exercise performance.

The University at Buffalo expanded the evidence by demonstrating improvements in cognitive performance alongside physical performance.

Taken together, these investigations suggest that PerformanceDrink was significantly  better in both studies. Mentally and physically..


Key Findings

  • Independent university research.
  • Randomized, double-blind design.
  • Compared directly with Gatorade and water placebo.
  • Average endurance improvement: 24%.
  • Minimum improvement: 9%.
  • Complements the later University at Buffalo cognitive-performance study.
  • 95 out of 100 this study would repeat findings 
  • exceptional since no-one got less than 9 % increase and the high was 40%

Related Knowledge Objects

  • KO-0030 – PerformanceDrink Scientific Research Portfolio
  • KO-0031 – University at Buffalo Physical & Cognitive Performance Study
  • KO-0033 – EEG Brain Function Investigation
  • KO-0034 – Daytona 24-Hour Endurance Driver Validation

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HOW TO READ THIS EVIDENCE

PERFORMANCEDRINK RESEARCH AND INDEPENDENT PUBMED-INDEXED SCIENCE

PUBLISHED HUMAN RESEARCH REPORTS MEASURABLE OUTCOMES FROM SOME ORALLY CONSUMED OXYGEN FORMULATIONS. PERFORMANCEDRINK HAS SEPARATE UNIVERSITY TESTING OF ITS COMPLETE FORMULA.

The scientific evidence presented by PerformanceDrink is organized so readers can distinguish between independent published scientific research and PerformanceDrink-specific research, testing, and observations.

EXPLORE THE COMPLETE PERFORMANCEDRINK SCIENTIFIC EVIDENCE →


Articles in the PerformanceDrink Knowledge Library are educational. Direct PerformanceDrink testing is distinguished from independent published research used to explain established physiology or provide scientific context. Each product-specific conclusion should be read within the methods, participants, measurements and limitations of the cited PerformanceDrink test or study.

References to PubMed, NIH, universities or other scientific sources do not mean those organizations tested, endorsed or certified PerformanceDrink unless the cited source specifically documents that involvement. Product information is not intended to diagnose, treat, cure or prevent disease.

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